Semaphorin 3A, a potential immune regulator in Familial Mediterranean Fever
نویسندگان
چکیده
منابع مشابه
Semaphorin 3A, a potential immune regulator in Familial Mediterranean Fever
OBJECTIVES Semaphorin 3A (sema3A) plays a regulatory role in immune responses with effects on both T and B regulatory cells. Familial Mediterranean fever (FMF) is an autoinflammatory disease, yet a possible role for regulatory T and B cells has been described. METHODS 17 FMF patients during attack and then in remission, 8 FMF patients with smoldering disease and 12 healthy controls were enrol...
متن کاملFAMILIAL MEDITERRANEAN FEVER: A STUDY OF 32 CASES
From April 1983 to September 1990, 32 patients with familial mediterranean fever (FMF) were studied. FMF is characterized by short, self-limited, febrile episodes that occur with inflammation of serosal surfaces. Major symptoms include fever and abdominal pain, presenting as acute surgical abdomen. These attacks are associated with considerable morbidity and in some patients lead to unnece...
متن کاملBone Mineral Density in Egyptian Children with Familial Mediterranean Fever
Background: Familial Mediterranean fever (FMF) has episodic or subclinical inflammation that may lead to a decrease in bone mineral density (BMD). The objective of this study was to assess BMD in Egyptian children with FMF on genetic basis.Methods: A cross sectional study included 45 FMF patients and 25 control children of both sexes in the age range between 3-16 years old. The patients were re...
متن کاملGenetic Analysis of Southwestern Iranian Patients with Familial Mediterranean Fever
Background: Familial Mediterranean fever (FMF) is an autosomal recessive genetic disorder characterized by recurrent episodes of self-limited fever and serosal tissues inflammation. Methods: To evaluate clinical symptoms and common genetic mutations in southwestern Iranian patients with FMF, 20 unrelated patients were enrolled in this study based on clinical criteria. A panel of 12 common ME...
متن کاملFamilial Mediterranean Fever
Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by MEditerranean FeVer gene (MEFV) mutations. In Japan, patients with FMF have been previously reported, including a mild or incomplete form. Several factors are presumed to contribute to the variable penetrance and to the phenotypic variability of FMF. We conducted the current study to investigate the correlation of varia...
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ژورنال
عنوان ژورنال: Pediatric Rheumatology
سال: 2015
ISSN: 1546-0096
DOI: 10.1186/1546-0096-13-s1-o46